Functional Neuroanatomy of Tics

Speaker: Grace Mucci, Ph.D., M.S., ABPdN, ABPP

Date: May 20, 2025

Article link

Time: 9:00 am PDT - 10:00 am PDT

Abstract: 

Clinicians have long been interested in tic disorders and have utilized functional MRI (fMRI) techniques to gain deeper insights into their underlying neurobiology. This month's Journal Club article presents a study exploring brain activity during various tic-related phenomena, including the premonitory urge, tic execution, and suppression, revealing the involvement of extensive brain networks. In particular, the cingulo-opercular action mode network plays a crucial role in both tic generation and regulation. By analyzing tic-related activity through a network-based perspective, the research provides valuable insights that could inform targeted therapeutic interventions.

Objectives:

1. List the functional brain networks involved in tic-related activity

2. Contrast the neural correlates of the pre-tic time period, tic release, and tic suppression

3. Examine emerging treatment approaches targeting tic-related activity